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When puppies are born, their immune system is not fully developed. This would normally leave the puppy open to many forms of infection. But, thanks to maternal antibodies, these puppies get immunity from their mother while in the uterus and also from the first couple days of her milk (colostrum). This is crucial for their survival. How long those antibodies last in any given puppy varies from individual to individual, even within the same litter. Maternal antibodies against different diseases even wear off at different times within the same puppy. While maternal antibodies are present in the puppy, any vaccines that are given to that puppy will be inactivated by Mom's antibodies without ever stimulating the puppy's own immune system. Because of this fact, we, as veterinarians, give a series of vaccines in order to stimulates that puppy's own antibodies. The problem is that we don't know when each puppy will become susceptible to the vaccine. Unfortunately, they must be susceptible to the virus in order for the vaccine to be effective (because that is when Mom's immunity wears off). The goal then becomes to get the vaccine in the puppy before he/she encounters the virus. We do know that at 16 weeks of age, maternal antibodies in 95% of all puppies are gone. That means that if you vaccinate your puppy at 16 weeks of age, there is a 95% chance that he is covered for those viruses you vaccinated against. However, when you vaccinate against a specific disease for the first time, even in an adult animal, it is best to give at least two vaccinations. This is because the second vaccination will produce a much greater response if it is following a vaccine given 2-4 weeks earlier. (The first one sort of "primes" the system.) So you ask, "Why don't we pull blood and check the puppy's antibody titers, to see when they need to be vaccinated?" Answer: Economics! It actually cost more to pull blood, send it off to the lab, wait on results, continue to re-check levels every couple of weeks, and then vaccinate when the titers drop. Other than that -- there is nothing wrong with that approach. At Sequoyah Animal Hospital, we use the following vaccination program:
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